Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals through the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor cell-microenvironment interaction... https://alexandert715uck8.blogdun.com/profile