You will find there's launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent discomfort transmission and deliver analgesia. Hence, drugs like clonidine that target alpha-2 receptors can impact the transmission of discomfort. Clonidine is dispersed in breast milk; https://waltz382edd7.wikicorrespondent.com/user