An extensive literature evaluation of reports between 1995 and 2018 was carried out utilizing the Digital databases PubMed and EBSCO Host. Lookups were performed making use of the next terms: whole knee arthroplasty (TKA); cyclooxygenase-two inhibitors; bracing; Bodily therapy; fat reduction; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; corticosteroid; https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/