There's a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to lower afferent ache transmission and create analgesia. Thus, medicines like clonidine that focus on alpha-2 receptors can influence the transmission of pain. Applies to clonidine: oral tablet, oral pill https://www.proleviate.com/post/the-new-pain-killer-conolidine